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pentobarbital will minimize the level or influence of acalabrutinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital will reduce the level or effect of brexpiprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Double brexpiprazole dose about 1-two months if